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KMID : 1101220010330020155
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2001 Volume.33 No. 2 p.155 ~ p.161
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Morphological and Biochemical Changes in Blood of Japanese Quail Treated with 6-Aminonicotinamide
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Lee Dong-Beom
Kim Tai-Jeon
Na Dong-Jin
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Abstract
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Effects of neurotoxin 6-aminonicotinamide (6-AN) on the morphological and biochemical changes in blood cells of Japanese quail were investigated. 6-AN stimulated the multiple appearance of tear drop cells and several blast cells such as pronormoblast, basophilic normoblast and polychromatophilic normoblast. In addition, the numbers of red blood cell, white blood cell and hemoglobin were severely reudced. In white blood cell, mother cells like myeloblast and promyelocyte were distinctively produced. Therefore, 6-AN appeared to interfere with the hematopoiesis occurring in the bone marrow. In the serum, the levels of total proteins and albumin were not affected, but the levels of globulin were significantly lower than those of the control and pair-fed groups. In contrast, the levels of glucose and total cholesterol were significantly elevated. The activity of aspartate aminotransferase and creatine phosphokinase were significantly higher than that of the control and pair-fed groups. The activity of lactate dehydrogenase of the 6-AN and pair-fed groups were higer than that of the control group. The result suggest that 6-AN may interfere with the proper maintenance of energy charges.
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KEYWORD
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6-Aminonicotinamide, Morphological and biochemical change, Serum
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